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What is Semaglutide?

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. It mimics the GLP-1 hormone that is released in the gastrointestinal tract in response to eating. One role of GLP-1 is to prompt the body to produce more insulin, which reduces blood glucose (sugar). GLP-1 in higher amounts also interacts with the parts of the brain that reduce appetite and signal a feeling of fullness.

What is Tirzepatide?

Tirzepatide is a once-weekly GIP (glucose-dependent insulinotropic polypeptide) receptor and GLP-1 (glucagon-like peptide-1) receptor agonist. Tirzepatide is a single molecule that activates the body’s receptors for GIP and GLP-1, which are natural incretin hormones. Both GIP and GLP-1 receptors are found in areas of the human brain important for appetite regulation. Tirzepatide has been shown to decrease food intake and modulate fat utilization.

A form of vitamin B3, niacinamide is recognized as being a leading benefit for cellular metabolism and skin health. Unlike Tirzepatide, it is not a weight-loss agent although it does play a significant role in metabolizing fat and producing energy. 

Niacinamide supports the processes of Tirzepatide by way of mitochondrial functions and through the regulation of inflammation. While perhaps indirectly, these functions, in turn, improve metabolic health and contribute to weight loss.

Used together, Tirzepatide and niacinamide allow for significant weight loss, with Tirzepatide controlling appetite and niacinamide working to maintain energy production for the cells.

Frequently Asked Questions About Weight Loss Injections

How do weight loss injections work in the body?

They slow down how fast your stomach empties to keep you feeling full longer and also influence the signals to your brain to reduce how hungry you feel and to reduce cravings. This helps you eat less and promotes weight loss.

Do I need to change my diet while using injections?

Yes. GLP-1 prescription medications work best for weight loss when used alongside a low-calorie, healthy diet and while avoiding foods high in fat and sugar.

Can I use weight loss injections with other treatments?

Yes. Studies show that combining GLP-1 injections with lifestyle changes can lead to greater weight loss than using one method alone. Another study reported that combining GLP-1 medications with endoscopic sleeve gastroplasty can lead to more weight loss than using either by itself.

How often do I need to take weight loss injections?

Most weight loss injections are taken once a week but there are a few that are administered daily.

What happens if I miss a dose?

Missing a dose of your medication can hinder your weight loss progress. If you miss a dose of your medication, you should follow your doctor’s instructions on when to take your next dose.

Will I regain weight after stopping injections?

Maybe. Weight gain is possible after stopping weight loss injections if healthy habits are not continued. Once the medication is stopped, many people experience serious hunger and cravings, which makes it harder to follow a low-calorie diet plan.

Are weight loss injections safe for long term use?

Many weight loss injections are approved to be used for an extended period of time but it is important to attend all your follow-up visits, so your doctor can monitor your progress and health.

Can these GLP-1 injections help with other health problems?

Yes. Weight loss injections can directly and indirectly improve certain metabolic conditions like blood sugar levels, blood pressure, as well as cholesterol levels and insulin resistance. Some patients may also see improvements in conditions like Type 2 Diabetes and Sleep Apnea as they begin to lose weight.

Do weight loss injections work the same for everyone?

No. Everyone’s body reacts differently to GLP-1 medications, which is one reason why it is so important to work with an experienced doctor. Your personal reaction to GLP-1 weight loss medication can be different depending on your medical history, current health, and how well you adhere to your treatment plan.