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What is Semaglutide?

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. It mimics the GLP-1 hormone that is released in the gastrointestinal tract in response to eating. One role of GLP-1 is to prompt the body to produce more insulin, which reduces blood glucose (sugar). GLP-1 in higher amounts also interacts with the parts of the brain that reduce appetite and signal a feeling of fullness.

What is Tirzepatide?

Tirzepatide is a once-weekly GIP (glucose-dependent insulinotropic polypeptide) receptor and GLP-1 (glucagon-like peptide-1) receptor agonist. Tirzepatide is a single molecule that activates the body’s receptors for GIP and GLP-1, which are natural incretin hormones. Both GIP and GLP-1 receptors are found in areas of the human brain important for appetite regulation. Tirzepatide has been shown to decrease food intake and modulate fat utilization.

A form of vitamin B3, niacinamide is recognized as being a leading benefit for cellular metabolism and skin health. Unlike Tirzepatide, it is not a weight-loss agent although it does play a significant role in metabolizing fat and producing energy. 

Niacinamide supports the processes of Tirzepatide by way of mitochondrial functions and through the regulation of inflammation. While perhaps indirectly, these functions, in turn, improve metabolic health and contribute to weight loss.

Used together, Tirzepatide and niacinamide allow for significant weight loss, with Tirzepatide controlling appetite and niacinamide working to maintain energy production for the cells.